A new article published in Clinical Reviews in Allergy & Immunology discussed that the prevalence of eczema has been on the rise, globally. Genetics and environmental factors are among a spectrum of triggers that contribute to the development of the disease, while the prevention of development of eczema may reduce the risk of future food allergies and asthma. The authors reported that this concept has prompted a variety of research into the area of primary prevention of eczema in infants—a growing body of research examining infants supplemented with probiotics, prebiotics or both (synbiotics) have often been compared with their breastfed counterparts. This paper reviewed the evidence for manipulating the microbiome in the prevention of eczema. The results revealed that altering the microbiome in non-breastfed infants at high risk of atopy with Lactobacillus strains when given both, prenatally followed by prolonged use (greater than 6 months) postnatally, aids in the primary prevention of eczema. In addition, prebiotics are beneficial for the primary prevention of eczema in formula-fed infants with prolonged use. It was stated that these observations are in agreement with the World Allergy Organization (WAO) recommendations that support interventions to manipulate the microbiome with both, probiotics and prebiotics.